Drug interactions
Amlodipine-perindopril + Terazosin
Severity: Moderate
Amlodipine-perindopril and Terazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Terazosin is an alpha-1 blocker that can cause first-dose and postural hypotension. With amlodipine and perindopril the blood pressure lowering is additive, increasing the risk of dizziness and syncope.
What this interaction means in plain words
Amlodipine-perindopril and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Terazosin belongs to Genitourinary.
Why it happens
Additive pharmacodynamic vasodilation and blood pressure lowering.
What to do
Start terazosin at the lowest dose at bedtime and titrate gradually. Monitor orthostatic blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Terazosin
- Alfuzosin + Terazosin Major
- Amifostine + Terazosin Major
- Avanafil + Terazosin Major
- Doxazosin + Terazosin Major
- Dutasteride-tamsulosin + Terazosin Major
- Lofexidine + Terazosin Major
Frequently asked questions
Can I take Amlodipine-perindopril with Terazosin?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Terazosin is an alpha-1 blocker that can cause first-dose and postural hypotension. With amlodipine and perindopril the blood pressure lowering is additive, increasing the risk of dizziness and syncope.
How serious is the interaction between Amlodipine-perindopril and Terazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start terazosin at the lowest dose at bedtime and titrate gradually. Monitor orthostatic blood pressure.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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