Drug interactions
Amlodipine-perindopril + Timolol
Severity: Moderate
Amlodipine-perindopril and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic timolol adds to the blood-pressure lowering of amlodipine and perindopril and may cause bradycardia or hypotension. Ophthalmic timolol can also be absorbed enough to contribute in susceptible patients.
What this interaction means in plain words
Amlodipine-perindopril and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects of beta-blockade, calcium channel blockade and ACE inhibition.
What to do
Monitor blood pressure and heart rate at initiation and after dose changes. Reduce doses if symptomatic hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Frequently asked questions
Can I take Amlodipine-perindopril with Timolol?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic timolol adds to the blood-pressure lowering of amlodipine and perindopril and may cause bradycardia or hypotension. Ophthalmic timolol can also be absorbed enough to contribute in susceptible patients.
How serious is the interaction between Amlodipine-perindopril and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate at initiation and after dose changes. Reduce doses if symptomatic hypotension or bradycardia occurs.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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