Drug interactions
Amobarbital + Bromocriptine
Severity: Moderate
Amobarbital and Bromocriptine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital induces CYP3A4 and may speed up the breakdown of bromocriptine, lowering its exposure. This can reduce control of prolactin excess, acromegaly or Parkinson disease symptoms.
What this interaction means in plain words
Amobarbital and Bromocriptine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Bromocriptine belongs to Central Nervous System.
Why it happens
Barbiturate induction of hepatic and intestinal CYP3A4 increases bromocriptine metabolism.
What to do
Monitor clinical response and prolactin or growth hormone levels as appropriate, and increase the bromocriptine dose if efficacy falls. Reassess the dose when amobarbital is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Bromocriptine
Frequently asked questions
Can I take Amobarbital with Bromocriptine?
MediHelp rates the interaction as moderate. Amobarbital and Bromocriptine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital induces CYP3A4 and may speed up the breakdown of bromocriptine, lowering its exposure. This can reduce control of prolactin excess, acromegaly or Parkinson disease symptoms.
How serious is the interaction between Amobarbital and Bromocriptine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and prolactin or growth hormone levels as appropriate, and increase the bromocriptine dose if efficacy falls. Reassess the dose when amobarbital is stopped.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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