Drug interactions
Amobarbital + Bupropion
Severity: Moderate
Amobarbital and Bupropion: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes and can lower bupropion concentrations while altering the proportion of its active metabolites. The net antidepressant effect and tolerability may be unpredictable.
What this interaction means in plain words
Amobarbital and Bupropion can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Bupropion belongs to Central Nervous System.
Why it happens
Barbiturate induction of CYP2B6 and other enzymes increases bupropion metabolism.
What to do
Monitor clinical response to bupropion and adjust the dose if efficacy is lost. Do not exceed the maximum labeled bupropion dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Bupropion?
MediHelp rates the interaction as moderate. Amobarbital and Bupropion can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce hepatic enzymes and can lower bupropion concentrations while altering the proportion of its active metabolites. The net antidepressant effect and tolerability may be unpredictable.
How serious is the interaction between Amobarbital and Bupropion?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to bupropion and adjust the dose if efficacy is lost. Do not exceed the maximum labeled bupropion dose.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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