Drug interactions
Amobarbital + Carbamazepine
Severity: Moderate
Amobarbital and Carbamazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital can induce the metabolism of carbamazepine and lower its serum concentration, which risks reduced seizure control. Both drugs also cause sedation, and carbamazepine can itself alter barbiturate levels.
What this interaction means in plain words
Amobarbital and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Carbamazepine belongs to Central Nervous System.
Why it happens
Barbiturate induction of CYP3A4 increases carbamazepine clearance, alongside additive CNS depression.
What to do
Measure carbamazepine concentrations when starting or stopping amobarbital and adjust the dose to response. Monitor for sedation and breakthrough seizures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Amobarbital with Carbamazepine?
MediHelp rates the interaction as moderate. Amobarbital and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital can induce the metabolism of carbamazepine and lower its serum concentration, which risks reduced seizure control. Both drugs also cause sedation, and carbamazepine can itself alter barbiturate levels.
How serious is the interaction between Amobarbital and Carbamazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure carbamazepine concentrations when starting or stopping amobarbital and adjust the dose to response. Monitor for sedation and breakthrough seizures.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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