Drug interactions
Amobarbital + Clarithromycin
Severity: Moderate
Amobarbital and Clarithromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes and may lower clarithromycin concentrations, potentially reducing antibacterial efficacy. Clinical evidence for amobarbital specifically is limited, and induction with short-term use is modest.
What this interaction means in plain words
Amobarbital and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Clarithromycin belongs to Anti Bacterial.
Why it happens
Amobarbital induces CYP3A4, increasing clarithromycin metabolism.
What to do
Monitor clinical response to clarithromycin during prolonged barbiturate therapy and consider an alternative antibiotic if therapy is failing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Clarithromycin?
MediHelp rates the interaction as moderate. Amobarbital and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce hepatic enzymes and may lower clarithromycin concentrations, potentially reducing antibacterial efficacy. Clinical evidence for amobarbital specifically is limited, and induction with short-term use is modest.
How serious is the interaction between Amobarbital and Clarithromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to clarithromycin during prolonged barbiturate therapy and consider an alternative antibiotic if therapy is failing.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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