Drug interactions
Amobarbital + Clomipramine
Severity: Moderate
Amobarbital and Clomipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital induces hepatic enzymes and can lower clomipramine levels, risking loss of antidepressant or anti-obsessional effect. The two also add to sedation, and clomipramine can reduce the seizure threshold.
What this interaction means in plain words
Amobarbital and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Clomipramine belongs to Central Nervous System.
Why it happens
Barbiturate induction of CYP1A2 and CYP3A4 increases clomipramine metabolism, with additive CNS depression.
What to do
Monitor clinical response, sedation and, where available, tricyclic plasma levels, and adjust the clomipramine dose. Review the dose when amobarbital is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Amobarbital with Clomipramine?
MediHelp rates the interaction as moderate. Amobarbital and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital induces hepatic enzymes and can lower clomipramine levels, risking loss of antidepressant or anti-obsessional effect. The two also add to sedation, and clomipramine can reduce the seizure threshold.
How serious is the interaction between Amobarbital and Clomipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response, sedation and, where available, tricyclic plasma levels, and adjust the clomipramine dose. Review the dose when amobarbital is started or stopped.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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