Drug interactions
Amobarbital + Flibanserin
Severity: Major
Amobarbital and Flibanserin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce CYP3A4 and can reduce flibanserin exposure, likely diminishing its efficacy. Barbiturates also add to the CNS depression caused by flibanserin.
What this interaction means in plain words
Amobarbital and Flibanserin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Flibanserin belongs to Genitourinary.
Why it happens
Induction of CYP3A4 by amobarbital increases flibanserin metabolism, and both agents cause additive CNS depression.
What to do
Avoid combining flibanserin with amobarbital. Choose an alternative to either agent where possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Flibanserin?
MediHelp rates the interaction as major. Amobarbital and Flibanserin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates induce CYP3A4 and can reduce flibanserin exposure, likely diminishing its efficacy. Barbiturates also add to the CNS depression caused by flibanserin.
How serious is the interaction between Amobarbital and Flibanserin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining flibanserin with amobarbital. Choose an alternative to either agent where possible.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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