Drug interactions
Amobarbital + Haloperidol
Severity: Moderate
Amobarbital and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital adds to haloperidol's sedative effects and can induce its metabolism, lowering haloperidol levels and possibly reducing antipsychotic control. The net effect can include both oversedation and loss of efficacy.
What this interaction means in plain words
Amobarbital and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Haloperidol belongs to Central Nervous System.
Why it happens
Additive CNS depression plus barbiturate induction of CYP3A4 increasing haloperidol clearance.
What to do
Monitor sedation and psychiatric symptom control, and adjust the haloperidol dose as needed; recheck when amobarbital is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Amobarbital with Haloperidol?
MediHelp rates the interaction as moderate. Amobarbital and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital adds to haloperidol's sedative effects and can induce its metabolism, lowering haloperidol levels and possibly reducing antipsychotic control. The net effect can include both oversedation and loss of efficacy.
How serious is the interaction between Amobarbital and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and psychiatric symptom control, and adjust the haloperidol dose as needed; recheck when amobarbital is started or stopped.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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