Drug interactions
Amobarbital + Iloperidone
Severity: Moderate
Amobarbital and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital may lower iloperidone exposure through CYP3A4 induction, reducing antipsychotic efficacy. Both drugs also cause sedation, so combined CNS depression and orthostatic effects may increase.
What this interaction means in plain words
Amobarbital and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Iloperidone belongs to Central Nervous System.
Why it happens
CYP3A4 induction increases iloperidone clearance, plus additive CNS depression.
What to do
Monitor psychiatric response and sedation; adjust the iloperidone dose if symptoms re-emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Amobarbital with Iloperidone?
MediHelp rates the interaction as moderate. Amobarbital and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital may lower iloperidone exposure through CYP3A4 induction, reducing antipsychotic efficacy. Both drugs also cause sedation, so combined CNS depression and orthostatic effects may increase.
How serious is the interaction between Amobarbital and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric response and sedation; adjust the iloperidone dose if symptoms re-emerge.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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