Drug interactions
Amobarbital + Mefloquine
Severity: Moderate
Amobarbital and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates are potent enzyme inducers and may lower mefloquine concentrations. This may reduce prophylactic or therapeutic efficacy against malaria.
What this interaction means in plain words
Amobarbital and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Mefloquine belongs to Anti Parasitic.
Why it happens
Amobarbital induces CYP3A4, increasing mefloquine metabolism.
What to do
Monitor for reduced antimalarial response, or choose an alternative agent if possible. Consider checking for breakthrough infection in prophylaxis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Mefloquine?
MediHelp rates the interaction as moderate. Amobarbital and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates are potent enzyme inducers and may lower mefloquine concentrations. This may reduce prophylactic or therapeutic efficacy against malaria.
How serious is the interaction between Amobarbital and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antimalarial response, or choose an alternative agent if possible. Consider checking for breakthrough infection in prophylaxis.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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