Drug interactions
Amobarbital + Perphenazine
Severity: Moderate
Amobarbital and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use increases sedation and CNS depression. Barbiturates may also reduce phenothiazine levels via enzyme induction, and phenothiazines can lower the seizure threshold.
What this interaction means in plain words
Amobarbital and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Perphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression plus barbiturate hepatic enzyme induction increasing perphenazine metabolism.
What to do
Monitor sedation, respiratory status and psychiatric response. Adjust the perphenazine dose if efficacy declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Amobarbital with Perphenazine?
MediHelp rates the interaction as moderate. Amobarbital and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use increases sedation and CNS depression. Barbiturates may also reduce phenothiazine levels via enzyme induction, and phenothiazines can lower the seizure threshold.
How serious is the interaction between Amobarbital and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, respiratory status and psychiatric response. Adjust the perphenazine dose if efficacy declines.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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