Drug interactions
Amobarbital + Pomalidomide
Severity: Minor
Amobarbital and Pomalidomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pomalidomide is partly metabolized by CYP3A4 and CYP1A2, so amobarbital may modestly lower its exposure. The clinical impact is uncertain but could reduce efficacy.
What this interaction means in plain words
Amobarbital and Pomalidomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amobarbital belongs to Central Nervous System; Pomalidomide belongs to Miscellaneous.
Why it happens
CYP3A4 induction by amobarbital may increase pomalidomide metabolism.
What to do
No empiric dose change is needed; monitor disease response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Pomalidomide
- Deferiprone + Pomalidomide Major
- Ethinyl estradiol-drospirenone + Pomalidomide Major
- Fluvoxamine + Pomalidomide Major
- Apalutamide + Pomalidomide Moderate
- Brivaracetam + Pomalidomide Moderate
- Carbamazepine + Pomalidomide Moderate
Frequently asked questions
Can I take Amobarbital with Pomalidomide?
MediHelp rates the interaction as minor. Amobarbital and Pomalidomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pomalidomide is partly metabolized by CYP3A4 and CYP1A2, so amobarbital may modestly lower its exposure. The clinical impact is uncertain but could reduce efficacy.
How serious is the interaction between Amobarbital and Pomalidomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed; monitor disease response.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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