Drug interactions
Amobarbital + Sirolimus
Severity: Moderate
Amobarbital and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital is a barbiturate that induces hepatic and intestinal enzymes, which can lower sirolimus exposure. Reduced sirolimus concentrations may lead to loss of immunosuppression and a higher risk of graft rejection.
What this interaction means in plain words
Amobarbital and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Sirolimus belongs to Miscellaneous.
Why it happens
Barbiturate induction of CYP3A4 (and P-glycoprotein) increases sirolimus metabolism and reduces its bioavailability.
What to do
Monitor sirolimus trough concentrations when starting or stopping amobarbital and adjust the sirolimus dose accordingly. Consider a non-inducing sedative alternative if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Amobarbital with Sirolimus?
MediHelp rates the interaction as moderate. Amobarbital and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital is a barbiturate that induces hepatic and intestinal enzymes, which can lower sirolimus exposure. Reduced sirolimus concentrations may lead to loss of immunosuppression and a higher risk of graft rejection.
How serious is the interaction between Amobarbital and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough concentrations when starting or stopping amobarbital and adjust the sirolimus dose accordingly. Consider a non-inducing sedative alternative if feasible.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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