Drug interactions
Amoxapine + Rolapitant
Severity: Moderate
Amoxapine and Rolapitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rolapitant is a long-acting CYP2D6 inhibitor and can raise concentrations of CYP2D6 substrates such as amoxapine for weeks. This may increase anticholinergic effects, sedation, arrhythmia and seizure risk.
What this interaction means in plain words
Amoxapine and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Rolapitant inhibits CYP2D6, decreasing the metabolism of amoxapine.
What to do
Monitor for tricyclic toxicity and consider lowering the amoxapine dose; the inhibition may persist for at least 28 days after rolapitant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Frequently asked questions
Can I take Amoxapine with Rolapitant?
MediHelp rates the interaction as moderate. Amoxapine and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rolapitant is a long-acting CYP2D6 inhibitor and can raise concentrations of CYP2D6 substrates such as amoxapine for weeks. This may increase anticholinergic effects, sedation, arrhythmia and seizure risk.
How serious is the interaction between Amoxapine and Rolapitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic toxicity and consider lowering the amoxapine dose; the inhibition may persist for at least 28 days after rolapitant.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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