Drug interactions
Amoxicillin + Candesartan-hydrochlorothiazide
Severity: Minor
Amoxicillin and Candesartan-hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
There is no clinically meaningful interaction between thiazide diuretics and amoxicillin at usual doses. A theoretical effect on renal tubular secretion has not been shown to matter in practice.
What this interaction means in plain words
Amoxicillin and Candesartan-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amoxicillin belongs to Anti Bacterial; Candesartan-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Theoretical competition for renal tubular secretion; not established as clinically relevant.
What to do
No dose adjustment is needed. Be aware of the theoretical effect only if renal function is markedly impaired.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Amoxicillin
- Amoxicillin + Methotrexate Major
- Amoxicillin + Bcg vaccine live Moderate
- Amoxicillin + Cholera vaccine Moderate
- Amoxicillin + Eravacycline Moderate
- Amoxicillin + Microbiota Moderate
- Amoxicillin + Mycophenolate Moderate
Frequently asked questions
Can I take Amoxicillin with Candesartan-hydrochlorothiazide?
MediHelp rates the interaction as minor. Amoxicillin and Candesartan-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. There is no clinically meaningful interaction between thiazide diuretics and amoxicillin at usual doses. A theoretical effect on renal tubular secretion has not been shown to matter in practice.
How serious is the interaction between Amoxicillin and Candesartan-hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Be aware of the theoretical effect only if renal function is markedly impaired.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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