Drug interactions
Amoxicillin + Chloramphenicol
Severity: Minor
Amoxicillin and Chloramphenicol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may antagonize the bactericidal activity of amoxicillin, mainly shown in vitro. Clinical impact is uncertain but could matter in severe infections.
What this interaction means in plain words
Amoxicillin and Chloramphenicol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amoxicillin belongs to Anti Bacterial; Chloramphenicol belongs to Anti Bacterial.
Why it happens
Pharmacodynamic antagonism: inhibition of protein synthesis and growth reduces penicillin killing.
What to do
Avoid combining in infections requiring bactericidal therapy; otherwise monitor clinical response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amoxicillin
- Amoxicillin + Methotrexate Major
- Amoxicillin + Bcg vaccine live Moderate
- Amoxicillin + Cholera vaccine Moderate
- Amoxicillin + Eravacycline Moderate
- Amoxicillin + Microbiota Moderate
- Amoxicillin + Mycophenolate Moderate
Other interactions of Chloramphenicol
Frequently asked questions
Can I take Amoxicillin with Chloramphenicol?
MediHelp rates the interaction as minor. Amoxicillin and Chloramphenicol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chloramphenicol may antagonize the bactericidal activity of amoxicillin, mainly shown in vitro. Clinical impact is uncertain but could matter in severe infections.
How serious is the interaction between Amoxicillin and Chloramphenicol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining in infections requiring bactericidal therapy; otherwise monitor clinical response.
What other medicines interact with Amoxicillin?
MediHelp also lists interactions of Amoxicillin with, for example, Methotrexate, Bcg vaccine live, Cholera vaccine. The full list is on the Amoxicillin page.
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