Drug interactions
Amoxicillin + Hydrochlorothiazide-losartan
Severity: Minor
Amoxicillin and Hydrochlorothiazide-losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxicillin is cleared by renal tubular secretion, and thiazides may modestly compete or reduce renal clearance, which could raise amoxicillin exposure slightly. The effect is small and rarely of clinical consequence.
What this interaction means in plain words
Amoxicillin and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amoxicillin belongs to Anti Bacterial; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Possible competition for renal tubular secretion and reduced renal clearance, with no firmly established effect.
What to do
No routine adjustment is needed. Consider monitoring renal function and for amoxicillin adverse effects in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Amoxicillin
- Amoxicillin + Methotrexate Major
- Amoxicillin + Bcg vaccine live Moderate
- Amoxicillin + Cholera vaccine Moderate
- Amoxicillin + Eravacycline Moderate
- Amoxicillin + Microbiota Moderate
- Amoxicillin + Mycophenolate Moderate
Frequently asked questions
Can I take Amoxicillin with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as minor. Amoxicillin and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amoxicillin is cleared by renal tubular secretion, and thiazides may modestly compete or reduce renal clearance, which could raise amoxicillin exposure slightly. The effect is small and rarely of clinical consequence.
How serious is the interaction between Amoxicillin and Hydrochlorothiazide-losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Consider monitoring renal function and for amoxicillin adverse effects in patients with renal impairment.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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