Drug interactions
Amoxicillin + Pexidartinib
Severity: Moderate
Amoxicillin and Pexidartinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib carries a boxed warning for serious hepatotoxicity, and amoxicillin (especially with clavulanate) can occasionally cause liver injury. Combined use may increase hepatic risk, although plain amoxicillin is rarely hepatotoxic.
What this interaction means in plain words
Amoxicillin and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amoxicillin belongs to Anti Bacterial; Pexidartinib belongs to Oncology.
Why it happens
Additive potential for hepatotoxicity; no pharmacokinetic mechanism is established.
What to do
Monitor liver tests more closely during any amoxicillin course in patients on pexidartinib, and stop if liver injury develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amoxicillin
- Amoxicillin + Methotrexate Major
- Amoxicillin + Bcg vaccine live Moderate
- Amoxicillin + Cholera vaccine Moderate
- Amoxicillin + Eravacycline Moderate
- Amoxicillin + Microbiota Moderate
- Amoxicillin + Mycophenolate Moderate
Other interactions of Pexidartinib
Frequently asked questions
Can I take Amoxicillin with Pexidartinib?
MediHelp rates the interaction as moderate. Amoxicillin and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pexidartinib carries a boxed warning for serious hepatotoxicity, and amoxicillin (especially with clavulanate) can occasionally cause liver injury. Combined use may increase hepatic risk, although plain amoxicillin is rarely hepatotoxic.
How serious is the interaction between Amoxicillin and Pexidartinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver tests more closely during any amoxicillin course in patients on pexidartinib, and stop if liver injury develops.
What other medicines interact with Amoxicillin?
MediHelp also lists interactions of Amoxicillin with, for example, Methotrexate, Bcg vaccine live, Cholera vaccine. The full list is on the Amoxicillin page.
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