Drug interactions
Amoxicillin + Sarecycline
Severity: Minor
Amoxicillin and Sarecycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetracyclines may theoretically reduce penicillin bactericidal effect. Sarecycline has low systemic exposure when used for acne, so clinical relevance is likely small.
What this interaction means in plain words
Amoxicillin and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amoxicillin belongs to Anti Bacterial; Sarecycline belongs to Anti Bacterial.
Why it happens
Bacteriostatic inhibition of protein synthesis may reduce growth-dependent beta-lactam killing.
What to do
No routine action is needed; monitor clinical response to amoxicillin in serious infections.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amoxicillin
- Amoxicillin + Methotrexate Major
- Amoxicillin + Bcg vaccine live Moderate
- Amoxicillin + Cholera vaccine Moderate
- Amoxicillin + Eravacycline Moderate
- Amoxicillin + Microbiota Moderate
- Amoxicillin + Mycophenolate Moderate
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Amoxicillin with Sarecycline?
MediHelp rates the interaction as minor. Amoxicillin and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tetracyclines may theoretically reduce penicillin bactericidal effect. Sarecycline has low systemic exposure when used for acne, so clinical relevance is likely small.
How serious is the interaction between Amoxicillin and Sarecycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; monitor clinical response to amoxicillin in serious infections.
What other medicines interact with Amoxicillin?
MediHelp also lists interactions of Amoxicillin with, for example, Methotrexate, Bcg vaccine live, Cholera vaccine. The full list is on the Amoxicillin page.
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