Drug interactions
Amoxicillin-clavulanic acid + Erythromycin lactobionate
Severity: Minor
Amoxicillin-clavulanic acid and Erythromycin lactobionate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bacteriostatic macrolides have been proposed to blunt the activity of bactericidal beta-lactams. Clinical evidence is limited and inconsistent, and the combination is often used, for example in community-acquired pneumonia.
What this interaction means in plain words
Amoxicillin-clavulanic acid and Erythromycin lactobionate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amoxicillin-clavulanic acid belongs to Anti Bacterial; Erythromycin lactobionate belongs to Anti Bacterial.
Why it happens
Theoretical pharmacodynamic antagonism: a bacteriostatic agent halts bacterial growth, reducing the growth-dependent killing by beta-lactams.
What to do
No routine change is needed; avoid relying on the combination when rapid bactericidal activity is essential, such as in meningitis.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amoxicillin-clavulanic acid
- Amoxicillin-clavulanic acid + Methotrexate Major
- Amoxicillin-clavulanic acid + Pexidartinib Major
- Amoxicillin-clavulanic acid + Pretomanid Major
- Allopurinol + Amoxicillin-clavulanic acid Moderate
- Amoxicillin-clavulanic acid + Bcg vaccine live Moderate
- Amoxicillin-clavulanic acid + Chloramphenicol Moderate
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Amoxicillin-clavulanic acid with Erythromycin lactobionate?
MediHelp rates the interaction as minor. Amoxicillin-clavulanic acid and Erythromycin lactobionate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bacteriostatic macrolides have been proposed to blunt the activity of bactericidal beta-lactams. Clinical evidence is limited and inconsistent, and the combination is often used, for example in community-acquired pneumonia.
How serious is the interaction between Amoxicillin-clavulanic acid and Erythromycin lactobionate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; avoid relying on the combination when rapid bactericidal activity is essential, such as in meningitis.
What other medicines interact with Amoxicillin-clavulanic acid?
MediHelp also lists interactions of Amoxicillin-clavulanic acid with, for example, Methotrexate, Pexidartinib, Pretomanid. The full list is on the Amoxicillin-clavulanic acid page.
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