Drug interactions
Amoxicillin-clavulanic acid + Estradiol
Severity: Minor
Amoxicillin-clavulanic acid and Estradiol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics have been theorised to reduce enterohepatic recycling of estrogens by altering gut flora, possibly lowering estrogen levels. Pharmacokinetic studies have largely not confirmed a meaningful reduction, and the risk of contraceptive failure is considered low.
What this interaction means in plain words
Amoxicillin-clavulanic acid and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amoxicillin-clavulanic acid belongs to Anti Bacterial; Estradiol belongs to Endocrine.
Why it happens
Theoretical reduction of enterohepatic recirculation of estrogen through altered intestinal flora.
What to do
No routine additional measures are needed; advise patients to report breakthrough bleeding or vomiting/diarrhea affecting oral hormone absorption.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amoxicillin-clavulanic acid
- Amoxicillin-clavulanic acid + Methotrexate Major
- Amoxicillin-clavulanic acid + Pexidartinib Major
- Amoxicillin-clavulanic acid + Pretomanid Major
- Allopurinol + Amoxicillin-clavulanic acid Moderate
- Amoxicillin-clavulanic acid + Bcg vaccine live Moderate
- Amoxicillin-clavulanic acid + Chloramphenicol Moderate
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Amoxicillin-clavulanic acid with Estradiol?
MediHelp rates the interaction as minor. Amoxicillin-clavulanic acid and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotics have been theorised to reduce enterohepatic recycling of estrogens by altering gut flora, possibly lowering estrogen levels. Pharmacokinetic studies have largely not confirmed a meaningful reduction, and the risk of contraceptive failure is considered low.
How serious is the interaction between Amoxicillin-clavulanic acid and Estradiol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine additional measures are needed; advise patients to report breakthrough bleeding or vomiting/diarrhea affecting oral hormone absorption.
What other medicines interact with Amoxicillin-clavulanic acid?
MediHelp also lists interactions of Amoxicillin-clavulanic acid with, for example, Methotrexate, Pexidartinib, Pretomanid. The full list is on the Amoxicillin-clavulanic acid page.
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