Drug interactions
Amoxicillin-clavulanic acid + Hydrochlorothiazide
Severity: Minor
Amoxicillin-clavulanic acid and Hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are eliminated partly by renal tubular secretion, so they might slightly raise each other's levels. No clinically significant effect is expected in patients with normal renal function.
What this interaction means in plain words
Amoxicillin-clavulanic acid and Hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amoxicillin-clavulanic acid belongs to Anti Bacterial; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Possible competition for renal tubular secretion.
What to do
No dose adjustment is usually required; monitor renal function and fluid status in elderly or renally impaired patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amoxicillin-clavulanic acid
- Amoxicillin-clavulanic acid + Methotrexate Major
- Amoxicillin-clavulanic acid + Pexidartinib Major
- Amoxicillin-clavulanic acid + Pretomanid Major
- Allopurinol + Amoxicillin-clavulanic acid Moderate
- Amoxicillin-clavulanic acid + Bcg vaccine live Moderate
- Amoxicillin-clavulanic acid + Chloramphenicol Moderate
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Amoxicillin-clavulanic acid with Hydrochlorothiazide?
MediHelp rates the interaction as minor. Amoxicillin-clavulanic acid and Hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both are eliminated partly by renal tubular secretion, so they might slightly raise each other's levels. No clinically significant effect is expected in patients with normal renal function.
How serious is the interaction between Amoxicillin-clavulanic acid and Hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required; monitor renal function and fluid status in elderly or renally impaired patients.
What other medicines interact with Amoxicillin-clavulanic acid?
MediHelp also lists interactions of Amoxicillin-clavulanic acid with, for example, Methotrexate, Pexidartinib, Pretomanid. The full list is on the Amoxicillin-clavulanic acid page.
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