Drug interactions
Amphotericin b + Lomustine
Severity: Moderate
Amphotericin b and Lomustine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphotericin B is nephrotoxic and lomustine can cause renal toxicity with prolonged use, so kidney injury may be more likely when they are combined. Myelosuppression from lomustine also increases vulnerability to fungal infection that requires amphotericin.
What this interaction means in plain words
Amphotericin b and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphotericin b belongs to Anti Fungals; Lomustine belongs to Oncology.
Why it happens
Additive nephrotoxicity; no specific pharmacokinetic interaction is established.
What to do
Monitor serum creatinine and electrolytes regularly and maintain hydration. Adjust doses or choose a less nephrotoxic antifungal formulation if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Amphotericin b with Lomustine?
MediHelp rates the interaction as moderate. Amphotericin b and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphotericin B is nephrotoxic and lomustine can cause renal toxicity with prolonged use, so kidney injury may be more likely when they are combined. Myelosuppression from lomustine also increases vulnerability to fungal infection that requires amphotericin.
How serious is the interaction between Amphotericin b and Lomustine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and electrolytes regularly and maintain hydration. Adjust doses or choose a less nephrotoxic antifungal formulation if renal function declines.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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