Drug interactions
Ampicillin + Hydrochlorothiazide
Severity: Minor
Ampicillin and Hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide may slightly reduce renal clearance of ampicillin and increase its levels. This is rarely clinically important given the wide therapeutic margin of ampicillin.
What this interaction means in plain words
Ampicillin and Hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ampicillin belongs to Anti Bacterial; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Competition for renal tubular secretion and reduced renal perfusion or volume depletion lowering clearance.
What to do
No adjustment is usually needed; consider renal function and dose in patients with renal impairment or volume depletion.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ampicillin
- Allopurinol + Ampicillin Moderate
- Ampicillin + Bcg vaccine live Moderate
- Ampicillin + Chloramphenicol Moderate
- Ampicillin + Chloroquine Moderate
- Ampicillin + Cholera vaccine Moderate
- Ampicillin + Demeclocycline Moderate
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Ampicillin with Hydrochlorothiazide?
MediHelp rates the interaction as minor. Ampicillin and Hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide may slightly reduce renal clearance of ampicillin and increase its levels. This is rarely clinically important given the wide therapeutic margin of ampicillin.
How serious is the interaction between Ampicillin and Hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is usually needed; consider renal function and dose in patients with renal impairment or volume depletion.
What other medicines interact with Ampicillin?
MediHelp also lists interactions of Ampicillin with, for example, Allopurinol, Bcg vaccine live, Chloramphenicol. The full list is on the Ampicillin page.
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