Drug interactions
Ampicillin-sulbactam + Esomeprazole
Severity: Minor
Ampicillin-sulbactam and Esomeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Raised gastric pH from acid suppression could modestly alter oral ampicillin absorption. Ampicillin-sulbactam is administered parenterally, so no meaningful effect is expected.
What this interaction means in plain words
Ampicillin-sulbactam and Esomeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ampicillin-sulbactam belongs to Anti Bacterial; Esomeprazole belongs to Gastrointestinal Tract.
Why it happens
Increased gastric pH may affect absorption of oral ampicillin; not relevant to parenteral use.
What to do
No action is needed with parenteral ampicillin-sulbactam; if oral ampicillin is used, monitor clinical response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ampicillin-sulbactam
Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Frequently asked questions
Can I take Ampicillin-sulbactam with Esomeprazole?
MediHelp rates the interaction as minor. Ampicillin-sulbactam and Esomeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Raised gastric pH from acid suppression could modestly alter oral ampicillin absorption. Ampicillin-sulbactam is administered parenterally, so no meaningful effect is expected.
How serious is the interaction between Ampicillin-sulbactam and Esomeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed with parenteral ampicillin-sulbactam; if oral ampicillin is used, monitor clinical response.
What other medicines interact with Ampicillin-sulbactam?
MediHelp also lists interactions of Ampicillin-sulbactam with, for example, Methotrexate, Allopurinol, Bcg vaccine live. The full list is on the Ampicillin-sulbactam page.
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