Drug interactions
Ampicillin-sulbactam + Metolazone
Severity: Minor
Ampicillin-sulbactam and Metolazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone may modestly reduce renal elimination of penicillins, with potentially higher antibiotic exposure. The effect is small and rarely relevant given the wide safety margin of ampicillin.
What this interaction means in plain words
Ampicillin-sulbactam and Metolazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ampicillin-sulbactam belongs to Anti Bacterial; Metolazone belongs to Cardiovascular.
Why it happens
Possible reduced renal clearance through tubular competition or volume depletion.
What to do
No routine adjustment is needed. Monitor renal function and adjust the antibiotic dose if renal impairment develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ampicillin-sulbactam
Other interactions of Metolazone
Frequently asked questions
Can I take Ampicillin-sulbactam with Metolazone?
MediHelp rates the interaction as minor. Ampicillin-sulbactam and Metolazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metolazone may modestly reduce renal elimination of penicillins, with potentially higher antibiotic exposure. The effect is small and rarely relevant given the wide safety margin of ampicillin.
How serious is the interaction between Ampicillin-sulbactam and Metolazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor renal function and adjust the antibiotic dose if renal impairment develops.
What other medicines interact with Ampicillin-sulbactam?
MediHelp also lists interactions of Ampicillin-sulbactam with, for example, Methotrexate, Allopurinol, Bcg vaccine live. The full list is on the Ampicillin-sulbactam page.
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