Drug interactions
Anagrelide + Arsenic trioxide
Severity: Major
Anagrelide and Arsenic trioxide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so giving them together raises the chance of marked QTc prolongation and torsades de pointes. Arsenic trioxide carries a boxed warning for QT prolongation and arrhythmia, which makes any added QT-active drug especially undesirable.
What this interaction means in plain words
Anagrelide and Arsenic trioxide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anagrelide belongs to Cardiovascular; Arsenic trioxide belongs to Oncology.
Why it happens
Additive pharmacodynamic prolongation of cardiac repolarization (QT interval).
What to do
Avoid the combination where possible and consider an alternative cytoreductive agent. If both are essential, obtain a baseline and serial ECGs and keep potassium and magnesium within normal range.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Other interactions of Arsenic trioxide
- Amiodarone + Arsenic trioxide Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Arsenic trioxide + Clomipramine Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Arsenic trioxide + Fluphenazine Contraindicated
- Arsenic trioxide + Gemifloxacin Contraindicated
Frequently asked questions
Can I take Anagrelide with Arsenic trioxide?
MediHelp rates the interaction as major. Anagrelide and Arsenic trioxide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so giving them together raises the chance of marked QTc prolongation and torsades de pointes. Arsenic trioxide carries a boxed warning for QT prolongation and arrhythmia, which makes any added QT-active drug especially undesirable.
How serious is the interaction between Anagrelide and Arsenic trioxide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and consider an alternative cytoreductive agent. If both are essential, obtain a baseline and serial ECGs and keep potassium and magnesium within normal range.
What other medicines interact with Anagrelide?
MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.
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