Drug interactions
Anagrelide + Lopinavir
Severity: Major
Anagrelide and Lopinavir: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir/ritonavir has been associated with QT prolongation, and anagrelide has a similar effect. The combination may increase arrhythmia risk, and ritonavir's CYP inhibition may also raise anagrelide levels.
What this interaction means in plain words
Anagrelide and Lopinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anagrelide belongs to Cardiovascular; Lopinavir belongs to Anti Virals.
Why it happens
Additive QT prolongation, with possible CYP1A2/CYP3A4 inhibition raising anagrelide exposure.
What to do
Avoid if possible. If both are needed, obtain a baseline ECG, monitor QTc and electrolytes, and watch for anagrelide adverse effects such as palpitations.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Anagrelide with Lopinavir?
MediHelp rates the interaction as major. Anagrelide and Lopinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lopinavir/ritonavir has been associated with QT prolongation, and anagrelide has a similar effect. The combination may increase arrhythmia risk, and ritonavir's CYP inhibition may also raise anagrelide levels.
How serious is the interaction between Anagrelide and Lopinavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If both are needed, obtain a baseline ECG, monitor QTc and electrolytes, and watch for anagrelide adverse effects such as palpitations.
What other medicines interact with Anagrelide?
MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.
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