Drug interactions
Anagrelide + Ozanimod
Severity: Moderate
Anagrelide and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can cause heart rate slowing and conduction effects, and anagrelide has QT-prolonging potential, so bradycardia could increase the risk of torsades. The QT effect of ozanimod itself is modest, so the interaction is largely theoretical.
What this interaction means in plain words
Anagrelide and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Anagrelide belongs to Cardiovascular; Ozanimod belongs to Central Nervous System.
Why it happens
Possible additive effects on cardiac conduction and repolarization; bradycardia from ozanimod may facilitate QT-related arrhythmia.
What to do
Obtain a baseline ECG before starting ozanimod and monitor heart rate and QTc, especially during initiation. Correct electrolyte disturbances.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Anagrelide with Ozanimod?
MediHelp rates the interaction as moderate. Anagrelide and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod can cause heart rate slowing and conduction effects, and anagrelide has QT-prolonging potential, so bradycardia could increase the risk of torsades. The QT effect of ozanimod itself is modest, so the interaction is largely theoretical.
How serious is the interaction between Anagrelide and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG before starting ozanimod and monitor heart rate and QTc, especially during initiation. Correct electrolyte disturbances.
What other medicines interact with Anagrelide?
MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.
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