Drug interactions
Anagrelide + Trazodone
Severity: Major
Anagrelide and Trazodone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anagrelide can cause QT prolongation, tachycardia and palpitations, and trazodone may add to the QT effect. The combination raises the risk of ventricular arrhythmia, especially in patients with cardiac disease.
What this interaction means in plain words
Anagrelide and Trazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anagrelide belongs to Cardiovascular; Trazodone belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Perform a cardiovascular evaluation and baseline ECG before combining them, and correct electrolyte abnormalities. Monitor the QTc during therapy or choose an alternative antidepressant.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Trazodone?
MediHelp rates the interaction as major. Anagrelide and Trazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Anagrelide can cause QT prolongation, tachycardia and palpitations, and trazodone may add to the QT effect. The combination raises the risk of ventricular arrhythmia, especially in patients with cardiac disease.
How serious is the interaction between Anagrelide and Trazodone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform a cardiovascular evaluation and baseline ECG before combining them, and correct electrolyte abnormalities. Monitor the QTc during therapy or choose an alternative antidepressant.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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