Drug interactions
Anagrelide + Vortioxetine
Severity: Moderate
Anagrelide and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anagrelide inhibits platelet aggregation and vortioxetine, like other serotonergic antidepressants, may impair platelet function. Together they may raise the risk of bleeding.
What this interaction means in plain words
Anagrelide and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Anagrelide belongs to Cardiovascular; Vortioxetine belongs to Central Nervous System.
Why it happens
Additive effects on platelet function from platelet inhibition and reduced platelet serotonin uptake.
What to do
Monitor for bruising, mucosal or gastrointestinal bleeding, and review other antiplatelet or anticoagulant use. Check blood counts as appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Vortioxetine?
MediHelp rates the interaction as moderate. Anagrelide and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anagrelide inhibits platelet aggregation and vortioxetine, like other serotonergic antidepressants, may impair platelet function. Together they may raise the risk of bleeding.
How serious is the interaction between Anagrelide and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bruising, mucosal or gastrointestinal bleeding, and review other antiplatelet or anticoagulant use. Check blood counts as appropriate.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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