Drug interactions
Anakinra + Lomustine
Severity: Moderate
Anakinra and Lomustine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomustine causes delayed and prolonged myelosuppression and anakinra can predispose to infection, particularly neutropenia-related infection. Combining them may increase the risk of serious infection.
What this interaction means in plain words
Anakinra and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Anakinra belongs to Musculoskeletal; Lomustine belongs to Oncology.
Why it happens
Additive immunosuppression from alkylating agent bone marrow suppression and IL-1 blockade.
What to do
Monitor complete blood counts, including neutrophils, and watch for infection. Anakinra labeling advises against use in neutropenia, so hold it if counts fall.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Anakinra
- Anakinra + Bcg vaccine live Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine live Contraindicated
- Anakinra + Measles mumps rubella and varicella vaccine live Contraindicated
- Anakinra + Measles vaccine Contraindicated
- Abatacept + Anakinra Major
Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Anakinra with Lomustine?
MediHelp rates the interaction as moderate. Anakinra and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomustine causes delayed and prolonged myelosuppression and anakinra can predispose to infection, particularly neutropenia-related infection. Combining them may increase the risk of serious infection.
How serious is the interaction between Anakinra and Lomustine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts, including neutrophils, and watch for infection. Anakinra labeling advises against use in neutropenia, so hold it if counts fall.
What other medicines interact with Anakinra?
MediHelp also lists interactions of Anakinra with, for example, Bcg vaccine live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Anakinra page.
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