Drug interactions
Anastrozole + Cisapride
Severity: Minor
Anastrozole and Cisapride: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anastrozole is not a clinically meaningful CYP3A4 inhibitor, so a significant rise in cisapride exposure is not expected. Cisapride has a narrow margin because of QT prolongation, but no real interaction is established for this pair.
What this interaction means in plain words
Anastrozole and Cisapride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Anastrozole belongs to Oncology; Cisapride belongs to Gastrointestinal Tract.
Why it happens
Only weak in vitro CYP inhibition is described for anastrozole; no clinically relevant effect on cisapride metabolism is established.
What to do
No specific action is needed beyond the usual cisapride precautions. Monitor the ECG if other QT-prolonging risks exist.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cisapride
- Apomorphine + Cisapride Contraindicated
- Artemether + Cisapride Contraindicated
- Azithromycin + Cisapride Contraindicated
- Ceritinib + Cisapride Contraindicated
- Chloroquine + Cisapride Contraindicated
- Cisapride + Citalopram Contraindicated
Other interactions of Anastrozole
- Anastrozole + Bazedoxifene / conjugated estrogens Contraindicated
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Anastrozole + Conjugated estrogens Contraindicated
- Anastrozole + Estradiol Contraindicated
- Anastrozole + Estrogens conjugated synthetic Contraindicated
- Anastrozole + Estrogens esterified Contraindicated
Frequently asked questions
Can I take Anastrozole with Cisapride?
MediHelp rates the interaction as minor. Anastrozole and Cisapride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Anastrozole is not a clinically meaningful CYP3A4 inhibitor, so a significant rise in cisapride exposure is not expected. Cisapride has a narrow margin because of QT prolongation, but no real interaction is established for this pair.
How serious is the interaction between Anastrozole and Cisapride?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond the usual cisapride precautions. Monitor the ECG if other QT-prolonging risks exist.
What other medicines interact with Cisapride?
MediHelp also lists interactions of Cisapride with, for example, Apomorphine, Artemether, Azithromycin. The full list is on the Cisapride page.
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