Drug interactions
Anti-thymocyte + Tacrolimus
Severity: Moderate
Anti-thymocyte and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithymocyte globulin is commonly combined with tacrolimus in transplant immunosuppression, but together they raise the risk of infection and lymphoproliferative disorders. This is an expected effect managed within protocols.
What this interaction means in plain words
Anti-thymocyte and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Anti-thymocyte belongs to Miscellaneous; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive immunosuppression through T-cell depletion and calcineurin inhibition.
What to do
Use under a transplant protocol with infection prophylaxis and monitor tacrolimus trough levels and infection signs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Anti-thymocyte
- Anti-thymocyte + Bcg vaccine live Contraindicated
- Anti-thymocyte + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Anti-thymocyte + Measles mumps and rubella vaccine live Contraindicated
- Anti-thymocyte + Measles mumps rubella and varicella vaccine live Contraindicated
- Anti-thymocyte + Measles vaccine Contraindicated
- Anti-thymocyte + Rotavirus oral vaccine live Contraindicated
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Anti-thymocyte with Tacrolimus?
MediHelp rates the interaction as moderate. Anti-thymocyte and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithymocyte globulin is commonly combined with tacrolimus in transplant immunosuppression, but together they raise the risk of infection and lymphoproliferative disorders. This is an expected effect managed within protocols.
How serious is the interaction between Anti-thymocyte and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use under a transplant protocol with infection prophylaxis and monitor tacrolimus trough levels and infection signs.
What other medicines interact with Anti-thymocyte?
MediHelp also lists interactions of Anti-thymocyte with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Anti-thymocyte page.
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