Drug interactions
Anti-thymocyte + Trastuzumab deruxtecan
Severity: Moderate
Anti-thymocyte and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab deruxtecan causes neutropenia and anti-thymocyte globulin causes leukopenia and profound immunosuppression. Combined use may increase serious infection risk.
What this interaction means in plain words
Anti-thymocyte and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Anti-thymocyte belongs to Miscellaneous; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive myelosuppression and immunosuppression.
What to do
Monitor blood counts and infection signs closely, and delay trastuzumab deruxtecan for significant neutropenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Anti-thymocyte
- Anti-thymocyte + Bcg vaccine live Contraindicated
- Anti-thymocyte + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Anti-thymocyte + Measles mumps and rubella vaccine live Contraindicated
- Anti-thymocyte + Measles mumps rubella and varicella vaccine live Contraindicated
- Anti-thymocyte + Measles vaccine Contraindicated
- Anti-thymocyte + Rotavirus oral vaccine live Contraindicated
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Anti-thymocyte with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Anti-thymocyte and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab deruxtecan causes neutropenia and anti-thymocyte globulin causes leukopenia and profound immunosuppression. Combined use may increase serious infection risk.
How serious is the interaction between Anti-thymocyte and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and infection signs closely, and delay trastuzumab deruxtecan for significant neutropenia.
What other medicines interact with Anti-thymocyte?
MediHelp also lists interactions of Anti-thymocyte with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Anti-thymocyte page.
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