Drug interactions
Apalutamide + Aripiprazole
Severity: Moderate
Apalutamide and Aripiprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a strong CYP3A4 inducer, and aripiprazole is metabolized by CYP3A4 and CYP2D6. Aripiprazole concentrations may fall, risking loss of efficacy.
What this interaction means in plain words
Apalutamide and Aripiprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Aripiprazole belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 increases aripiprazole clearance.
What to do
Monitor psychiatric response and consider doubling the aripiprazole dose, as labeling suggests for strong CYP3A4 inducers. Reduce the dose again when apalutamide is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Aripiprazole?
MediHelp rates the interaction as moderate. Apalutamide and Aripiprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is a strong CYP3A4 inducer, and aripiprazole is metabolized by CYP3A4 and CYP2D6. Aripiprazole concentrations may fall, risking loss of efficacy.
How serious is the interaction between Apalutamide and Aripiprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric response and consider doubling the aripiprazole dose, as labeling suggests for strong CYP3A4 inducers. Reduce the dose again when apalutamide is stopped.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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