Drug interactions
Apalutamide + Celecoxib
Severity: Moderate
Apalutamide and Celecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide induces CYP2C9, the main enzyme metabolizing celecoxib, so celecoxib exposure may fall and its analgesic or anti-inflammatory effect may weaken.
What this interaction means in plain words
Apalutamide and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Celecoxib belongs to Musculoskeletal.
Why it happens
CYP2C9 induction by apalutamide increases celecoxib metabolic clearance.
What to do
Monitor for reduced efficacy of celecoxib and titrate within the labeled dose range or choose an alternative analgesic if response is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Celecoxib?
MediHelp rates the interaction as moderate. Apalutamide and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide induces CYP2C9, the main enzyme metabolizing celecoxib, so celecoxib exposure may fall and its analgesic or anti-inflammatory effect may weaken.
How serious is the interaction between Apalutamide and Celecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced efficacy of celecoxib and titrate within the labeled dose range or choose an alternative analgesic if response is lost.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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