Drug interactions
Apalutamide + Chloramphenicol
Severity: Minor
Apalutamide and Chloramphenicol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may inhibit CYP3A4 and raise apalutamide concentrations. Because apalutamide is also a CYP3A4 inducer and its exposure is only moderately affected by CYP3A4 inhibitors, the effect is likely modest.
What this interaction means in plain words
Apalutamide and Chloramphenicol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Apalutamide belongs to Endocrine; Chloramphenicol belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4-mediated metabolism of apalutamide.
What to do
No initial dose adjustment is needed. Monitor for adverse effects such as rash, fatigue and falls, and reduce the dose if poorly tolerated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chloramphenicol
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Chloramphenicol?
MediHelp rates the interaction as minor. Apalutamide and Chloramphenicol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chloramphenicol may inhibit CYP3A4 and raise apalutamide concentrations. Because apalutamide is also a CYP3A4 inducer and its exposure is only moderately affected by CYP3A4 inhibitors, the effect is likely modest.
How serious is the interaction between Apalutamide and Chloramphenicol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No initial dose adjustment is needed. Monitor for adverse effects such as rash, fatigue and falls, and reduce the dose if poorly tolerated.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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