Drug interactions
Apalutamide + Chlorothiazide
Severity: Minor
Apalutamide and Chlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a weak inducer of BCRP and could lower the systemic exposure of BCRP substrates. The clinical effect on chlorothiazide is probably small and not well documented.
What this interaction means in plain words
Apalutamide and Chlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Apalutamide belongs to Endocrine; Chlorothiazide belongs to Cardiovascular.
Why it happens
Apalutamide may weakly induce BCRP-mediated efflux, reducing chlorothiazide absorption.
What to do
No dose change is required. Monitor blood pressure and fluid status if diuretic response seems diminished.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Apalutamide with Chlorothiazide?
MediHelp rates the interaction as minor. Apalutamide and Chlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Apalutamide is a weak inducer of BCRP and could lower the systemic exposure of BCRP substrates. The clinical effect on chlorothiazide is probably small and not well documented.
How serious is the interaction between Apalutamide and Chlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is required. Monitor blood pressure and fluid status if diuretic response seems diminished.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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