Drug interactions
Apalutamide + Cilostazol
Severity: Moderate
Apalutamide and Cilostazol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a strong CYP3A4 and CYP2C19 inducer and may lower cilostazol and active metabolite exposure. This may reduce the benefit for intermittent claudication.
What this interaction means in plain words
Apalutamide and Cilostazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Cilostazol belongs to Cardiovascular.
Why it happens
Induction of CYP3A4 and CYP2C19 increases cilostazol clearance.
What to do
Assess for loss of symptom benefit and consider an alternative therapy if the response is lost. Dose adjustment is rarely practical.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Cilostazol?
MediHelp rates the interaction as moderate. Apalutamide and Cilostazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is a strong CYP3A4 and CYP2C19 inducer and may lower cilostazol and active metabolite exposure. This may reduce the benefit for intermittent claudication.
How serious is the interaction between Apalutamide and Cilostazol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess for loss of symptom benefit and consider an alternative therapy if the response is lost. Dose adjustment is rarely practical.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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