Drug interactions
Apalutamide + Clopidogrel
Severity: Moderate
Apalutamide and Clopidogrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clopidogrel's acyl glucuronide metabolite inhibits CYP2C8, which can raise exposure to apalutamide and its active metabolite. Apalutamide is also a CYP inducer that may alter clopidogrel activation, so exposure of both drugs may change.
What this interaction means in plain words
Apalutamide and Clopidogrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Clopidogrel belongs to Cardiovascular.
Why it happens
CYP2C8 inhibition by clopidogrel metabolite reduces apalutamide clearance, while apalutamide induction of CYP2C19 and CYP3A4 may change clopidogrel activation.
What to do
Monitor for apalutamide adverse effects such as rash, fatigue and falls, reducing the dose if poorly tolerated; watch for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clopidogrel
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Clopidogrel?
MediHelp rates the interaction as moderate. Apalutamide and Clopidogrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clopidogrel's acyl glucuronide metabolite inhibits CYP2C8, which can raise exposure to apalutamide and its active metabolite. Apalutamide is also a CYP inducer that may alter clopidogrel activation, so exposure of both drugs may change.
How serious is the interaction between Apalutamide and Clopidogrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for apalutamide adverse effects such as rash, fatigue and falls, reducing the dose if poorly tolerated; watch for bleeding.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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