Drug interactions
Apalutamide + Diclofenac
Severity: Minor
Apalutamide and Diclofenac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide induces CYP2C9, the main enzyme metabolizing diclofenac, which may lower diclofenac exposure and reduce analgesic or anti-inflammatory effect.
What this interaction means in plain words
Apalutamide and Diclofenac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Apalutamide belongs to Endocrine; Diclofenac belongs to Musculoskeletal.
Why it happens
Induction of CYP2C9 by apalutamide increases diclofenac metabolism.
What to do
Monitor for loss of analgesic efficacy and adjust therapy if needed, avoiding exceeding the maximum diclofenac dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Diclofenac?
MediHelp rates the interaction as minor. Apalutamide and Diclofenac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Apalutamide induces CYP2C9, the main enzyme metabolizing diclofenac, which may lower diclofenac exposure and reduce analgesic or anti-inflammatory effect.
How serious is the interaction between Apalutamide and Diclofenac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of analgesic efficacy and adjust therapy if needed, avoiding exceeding the maximum diclofenac dose.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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