Drug interactions
Apalutamide + Dutasteride-tamsulosin
Severity: Moderate
Apalutamide and Dutasteride-tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a strong CYP3A4 inducer and can lower exposure to CYP3A4 substrates such as tamsulosin and dutasteride. This may reduce relief of urinary symptoms and reduce dutasteride effect.
What this interaction means in plain words
Apalutamide and Dutasteride-tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Dutasteride-tamsulosin belongs to Genitourinary.
Why it happens
Induction of CYP3A4 by apalutamide increases the metabolism of tamsulosin and dutasteride.
What to do
Monitor urinary symptom control and consider alternative therapy if efficacy is lost. Reassess the need for the alpha-blocker or dose as clinically indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Dutasteride-tamsulosin?
MediHelp rates the interaction as moderate. Apalutamide and Dutasteride-tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is a strong CYP3A4 inducer and can lower exposure to CYP3A4 substrates such as tamsulosin and dutasteride. This may reduce relief of urinary symptoms and reduce dutasteride effect.
How serious is the interaction between Apalutamide and Dutasteride-tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urinary symptom control and consider alternative therapy if efficacy is lost. Reassess the need for the alpha-blocker or dose as clinically indicated.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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