Drug interactions
Apalutamide + Fluticasone-vilanterol
Severity: Moderate
Apalutamide and Fluticasone-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a strong CYP3A4 inducer and may reduce exposure to fluticasone furoate and to vilanterol, both CYP3A4 substrates. The result may be reduced control of asthma or COPD.
What this interaction means in plain words
Apalutamide and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Fluticasone-vilanterol belongs to Respiratory.
Why it happens
Induction of CYP3A4 (and P-gp) increases clearance of fluticasone furoate and vilanterol.
What to do
Monitor respiratory symptoms and exacerbation frequency during apalutamide therapy. Consider adjusting the maintenance regimen if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Fluticasone-vilanterol?
MediHelp rates the interaction as moderate. Apalutamide and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is a strong CYP3A4 inducer and may reduce exposure to fluticasone furoate and to vilanterol, both CYP3A4 substrates. The result may be reduced control of asthma or COPD.
How serious is the interaction between Apalutamide and Fluticasone-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory symptoms and exacerbation frequency during apalutamide therapy. Consider adjusting the maintenance regimen if control worsens.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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