Drug interactions
Apalutamide + Fluticasone
Severity: Moderate
Apalutamide and Fluticasone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a strong inducer of CYP3A4 and can speed up the clearance of fluticasone. This may lower corticosteroid exposure and reduce control of asthma, rhinitis or other inflammatory conditions.
What this interaction means in plain words
Apalutamide and Fluticasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Fluticasone belongs to Respiratory.
Why it happens
Induction of CYP3A4 by apalutamide increases the metabolism of fluticasone.
What to do
Monitor for loss of symptom control and consider an alternative corticosteroid or adjusted therapy if efficacy falls. Reassess the regimen when apalutamide is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Fluticasone?
MediHelp rates the interaction as moderate. Apalutamide and Fluticasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is a strong inducer of CYP3A4 and can speed up the clearance of fluticasone. This may lower corticosteroid exposure and reduce control of asthma, rhinitis or other inflammatory conditions.
How serious is the interaction between Apalutamide and Fluticasone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of symptom control and consider an alternative corticosteroid or adjusted therapy if efficacy falls. Reassess the regimen when apalutamide is started or stopped.
What other medicines interact with Fluticasone?
MediHelp also lists interactions of Fluticasone with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Fluticasone page.
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