Drug interactions
Apalutamide + Metaxalone
Severity: Moderate
Apalutamide and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a strong CYP3A4 inducer and metaxalone is partly metabolised by CYP3A4 among other enzymes. Exposure to metaxalone may fall, reducing muscle relaxant effect.
What this interaction means in plain words
Apalutamide and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Metaxalone belongs to Musculoskeletal.
Why it happens
Induction of CYP3A4 (and other enzymes) by apalutamide increases metaxalone metabolism.
What to do
Monitor for loss of efficacy and consider another muscle relaxant if response is inadequate. Avoid dose escalation beyond labelled limits.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Metaxalone?
MediHelp rates the interaction as moderate. Apalutamide and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is a strong CYP3A4 inducer and metaxalone is partly metabolised by CYP3A4 among other enzymes. Exposure to metaxalone may fall, reducing muscle relaxant effect.
How serious is the interaction between Apalutamide and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of efficacy and consider another muscle relaxant if response is inadequate. Avoid dose escalation beyond labelled limits.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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