Drug interactions
Apalutamide + Naloxegol
Severity: Moderate
Apalutamide and Naloxegol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide can reduce naloxegol exposure because naloxegol is a CYP3A4 and P-gp substrate. Efficacy in opioid-induced constipation may drop.
What this interaction means in plain words
Apalutamide and Naloxegol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Naloxegol belongs to Gastrointestinal Tract.
Why it happens
Apalutamide induces CYP3A4 and P-gp, increasing naloxegol clearance.
What to do
Avoid concurrent use as labeling advises against strong CYP3A4 inducers; use another laxative if response is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Naloxegol
- Clarithromycin + Naloxegol Contraindicated
- Itraconazole + Naloxegol Contraindicated
- Ketoconazole + Naloxegol Contraindicated
- Naloxegol + Posaconazole Contraindicated
- Naloxegol + Voriconazole Contraindicated
- Bupropion-naltrexone + Naloxegol Major
Frequently asked questions
Can I take Apalutamide with Naloxegol?
MediHelp rates the interaction as moderate. Apalutamide and Naloxegol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide can reduce naloxegol exposure because naloxegol is a CYP3A4 and P-gp substrate. Efficacy in opioid-induced constipation may drop.
How serious is the interaction between Apalutamide and Naloxegol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use as labeling advises against strong CYP3A4 inducers; use another laxative if response is lost.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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