Drug interactions
Apalutamide + Oliceridine
Severity: Moderate
Apalutamide and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oliceridine is metabolized mainly by CYP3A4 and CYP2D6. Apalutamide induces CYP3A4, which can reduce opioid exposure and analgesia, and stopping apalutamide later could raise levels and the risk of respiratory depression.
What this interaction means in plain words
Apalutamide and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Oliceridine belongs to Musculoskeletal.
Why it happens
Apalutamide induces CYP3A4, increasing the metabolism of oliceridine.
What to do
Titrate oliceridine to effect and monitor for withdrawal or inadequate analgesia. If apalutamide is discontinued, reduce the oliceridine dose and monitor for respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Apalutamide with Oliceridine?
MediHelp rates the interaction as moderate. Apalutamide and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oliceridine is metabolized mainly by CYP3A4 and CYP2D6. Apalutamide induces CYP3A4, which can reduce opioid exposure and analgesia, and stopping apalutamide later could raise levels and the risk of respiratory depression.
How serious is the interaction between Apalutamide and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate oliceridine to effect and monitor for withdrawal or inadequate analgesia. If apalutamide is discontinued, reduce the oliceridine dose and monitor for respiratory depression.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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