Drug interactions
Apalutamide + Rosuvastatin
Severity: Moderate
Apalutamide and Rosuvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide induces several drug-handling pathways and may lower the blood concentrations of rosuvastatin. This could reduce the cholesterol-lowering effect of the statin.
What this interaction means in plain words
Apalutamide and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Rosuvastatin belongs to Cardiovascular.
Why it happens
Apalutamide weakly induces BCRP and OATP1B1 and induces UGT, which may increase rosuvastatin clearance and lower its exposure.
What to do
Check the lipid profile after apalutamide is started or stopped. Increase the rosuvastatin dose if lipid control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosuvastatin
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Rosuvastatin?
MediHelp rates the interaction as moderate. Apalutamide and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide induces several drug-handling pathways and may lower the blood concentrations of rosuvastatin. This could reduce the cholesterol-lowering effect of the statin.
How serious is the interaction between Apalutamide and Rosuvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the lipid profile after apalutamide is started or stopped. Increase the rosuvastatin dose if lipid control is lost.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporin, Darolutamide. The full list is on the Rosuvastatin page.
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